Tea and carrots helped researchers free Alzheimer39s disease amp nbsp



MOSKOV, MARCH 7 – RIA News. Tea and carrot extracts stopped the development of Alzheimer's disease and restored memory in mice genetically predisposed to accumulating "debris" in their brain cells. The results of these experiments were presented in the Journal of Biological Chemistry. "In just three months of testing, we have been able to completely restore the memory of these mice. Moreover, you do not have to wait 10-12 years before the first drugs appear on the basis of these drugs – you can achieve some positive effect just by change the diet today, "said Terrence Town from Saitama University (Japan). Alzheimer's disease is believed to be due to the accumulation of a pathogenic substance, beta-amyloid protein, within neurons. It is formed by the "scrap" of the APP protein, which is involved in the repair of damaged neurons and the formation of connections between them. Disorders in the treatment of the molecules of this protein lead to the appearance of beta-amyloid plaques and the destruction of nerve cells. In recent years, biologists have noticeably advanced to understand what causes this disease and what it represents. However, all of the drugs created in recent years that stop or decrease the accumulation of beta-amyloid in the brain have failed in clinical trials or have been shown to be uncertain for humans. For several years, Town and his colleagues have been studying how various phytohormones, proteins and signaling agents present in plant and tissue tissues affect the formation of APP scrapes and their conversion to amyloid plaques. They were interested in the molecules that interact with the three key proteins responsible for "cutting" APP molecules. One of them, alpha secretase, destroys them in such a way that there are no tangles of protein waste in the cells, and the other two, beta and gamma secretase, produce two types of building blocks of amyloid plaques, ab40 and ab42. As a biologist explains, alpha secretase dominates in healthy neurons so that amyloid plaques do not accumulate in them. Guided by this idea, the bar group and dozens of other scientists try to create or open molecules that stimulate the production of the first enzyme and inhibit the activity of the other two activities. Recently, Japanese researchers discovered similar properties in two molecules – the substance EGCG, one of the major antioxidants in green tea and ferulic acid, found in the orange pulp of carrots, oranges and in the fruits of many other plants. The first, as demonstrated by cell culture experiments, not only protects the DNA from damage, but also enhances the alpha secretase activity and the other inhibits beta secretase. After receiving large amounts of these drugs, the city and his team controlled what would happen if they were injected into the mouse's body that was exposed to developing Alzheimer's disease in large quantities. As these experiments showed, the combination of carrot and tea extracts affected the brain of mice much more than these drugs worked separately. Just three months after switching to a diet with a large amount of ferulic acid and EGCG, the concentration of "building blocks" of amyloid plaques in the mice in mice fell sharply and their cognitive abilities improved significantly. In particular, their episodic memory became as good as in healthy mice of the same age, and their ability to remember events from the distant past and recognize new objects for themselves improved about. 1.5 times. All of these positive changes were accompanied by the fact that the number of beta-amyloid plaques in their memory center and other areas of the brain decreased by approx. 2-2.5 times. All of this, according to researchers, says that these molecules of vegetable origin can be used to fight Alzheimer's disease, including because they are safe for humans and easily penetrate the barrier between the circulatory system and brain tissue.



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